abstract：:Gastric cancer (GC) remains a major public health problem. Ursolic acid (UA) is reported to be effective in inhibiting GC; however, its low solubility and poor biocompatibility have greatly hindered its clinical application. Herein, an innovative reactive oxygen species (ROS)-sensitive UA dimeric prodrug is developed ...

authors： Ma J,Chen Y,Liang W,Li L,Du J,Pan C,Zhang C

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The elderly population deals with multimorbidity (three chronic conditions) and increasinged drug use with age. A comprehensive characterisation of the medication - including prescription and over-the-counter (OTC) drugs - of elderly patients in primary care is still insufficient. OBJECTIVES:This study aims...

authors： Krüger C,Schäfer I,van den Bussche H,Baehr M,Bickel H,Fuchs A,Gensichen J,Maier W,Riedel-Heller SG,König HH,Dahlhaus A,Schön G,Weyerer S,Wiese B,von Renteln-Kruse W,Langebrake C,Scherer M

更新日期：2021-12-01 00:00:00

abstract：:Influenza A viruses cause important diseases in both human and animal. The PB1-F2 protein is a virulence factor expressed by some influenza viruses. Its deleterious action for the infected host is mostly described in mammals, while the available information is scarce in avian hosts. In this work, we compared the effec...

authors： Mettier J,Marc D,Sedano L,Da Costa B,Chevalier C,Le Goffic R

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:There are no robust national prevalence of Human Papillomavirus (HPV) genotypes in Nigerian women despite the high burden of cervical cancer morbidity and mortality. THE OBJECTIVE OF STUDY:This study aims to determine the pooled prevalence and risk factors of genital HPV infection in Nigeria through a syste...

authors： Emeribe AU,Abdullahi IN,Etukudo MH,Isong IK,Emeribe AO,Nwofe JO,Umeozuru CM,Shuaib BI,Ajagbe ORO,Dangana A,Egenti BN,Ghamba PE

更新日期：2021-12-01 00:00:00

abstract：Background:During the first wave of COVID-19 it was hypothesized that COVID-19 is subject to multi-wave seasonality, similar to Influenza-Like Illnesses since time immemorial. One year into the pandemic, we aimed to test the seasonality hypothesis for COVID-19. Methods:We calculated the average annual time-series for ...

authors： Hoogeveen MJ,Hoogeveen EK

更新日期：2021-12-01 00:00:00

abstract：:During inflammation, inflammatory cells are rapidly recruited to sites of infection or injury, where they cross physiological barriers around the infected site and further infiltrate into the tissues. Other cells, such as erythrocytes, endothelial cells and stem cells, also play prominent roles in host defense and tis...

authors： Zhang R,Wu S,Ding Q,Fan Q,Dai Y,Guo S,Ye Y,Li C,Zhou M

更新日期：2021-12-01 00:00:00

abstract：:Emerging evidence has exhibited an obvious decreased expression of miR-106a-5p in the ectopic endometrial tissue of endometriosis (EMS) patients. Thus far, the pathophysiological function of miR-106a-5p in EMS is unknown. A previous study showed an increased FOXC1 expression in the ectopic endometrial tissue of patien...

authors： Zhou X,Chen Z,Pei L,Sun J

更新日期：2021-12-01 00:00:00

abstract：:Nematode chitinases play vital roles in various physiological processes, including egg hatching, larva moulting, and reproduction. Small-molecule inhibitors of nematode chitinases have potential applications for controlling nematode pests. On the basis of the crystal structure of CeCht1, a representative chitinase ind...

authors： Chen W,Chen Q,Kumar A,Jiang X,Zhang KYJ,Yang Q

更新日期：2021-12-01 00:00:00

abstract：:In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-...

authors： Zhang Y,Wang Q,Li L,Le Y,Liu L,Yang J,Li Y,Bao G,Yan L

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:After being steamed, the restorative effects of Panax notoginseng (Burk.) F. H. Chen (Araliaceae) will be strengthened. However, the underlying mechanism remains elusive. OBJECTIVE:To compare the pharmacokinetics of ginsenosides Rg1, Rb1, Rd, Re, Rg5, Rk1, notoginsenoside R1 (GRg1, GRb1, GRd, GRe, GRg5, GRk1 a...

authors： Dong J,Yin Z,Su L,Yu M,Wang M,Li L,Mao C,Lu T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Hypoxia-reperfusion (HR) and inflammation are causes of renal allograft injury. Pathological evidence has indicated that ischemia followed by reperfusion leads to the proteolysis and destruction of the extracellular matrix (ECM) in renal tubular epithelial cells. Matrix metalloproteinases (MMPs), such as MMP...

authors： Dong Y,Zhao H,Man J,Fu S,Yang L

更新日期：2021-12-01 00:00:00

abstract：:Exploring the influence of different incision designs on bone increment of guided bone regeneration [Bio-Gide collagen membrane +Bio-OSS bone powder (carbonate apatite crystal extracted from bovine bones), Bio-OSS bone meal was placed on the surface of the bone defect and then covered with a Bio-Gide membrane to close...

authors： Zhuang G,Mao J,Yang G,Wang H

更新日期：2021-12-01 00:00:00

abstract：:Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of pat...

authors： Yang Y,Long X,Li G,Yu X,Liu Y,Li K,Tian X

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Circulating intact parathyroid hormone (iPTH) levels include full-length (1-84) PTH and long C-PTH fragments, but primarily (7-84) PTH, which have been reported to have antagonistic effects on the bones and kidneys. However, their effects on the cardiovascular system remain unclear. In this study, the rela...

authors： Chen H,Ren W,Gao Z,Zeng M,Tang S,Xu F,Huang Y,Zhang L,Cui Y,Yang G,Qian H,Zhou W,Ouyang C,Gao X,Zhang J,Xiao Y,Zhao B,Wang J,Bian A,Li F,Wan H,Gao W,Wang X,Xing C,Zha X,Wang N

更新日期：2021-12-01 00:00:00

abstract：:ABSTRACTThe World Health Organization (WHO) introduced the new dengue classification in 2009. We aimed to assess the association of clinical signs and symptoms with WHO severe dengue classification in clinical practice. A systematic literature search was performed using the databases of PubMed, Embase, and Scopus betw...

authors： Htun TP,Xiong Z,Pang J

更新日期：2021-12-01 00:00:00

abstract：:Acute kidney injury (AKI) was a frequent complication following hip fracture surgery, but recent studies reported inconsistent findings. Our study was aimed at clarifying the prevalence and risk factors of AKI after hip fracture surgery. Pubmed, Embase, and Web of Science were systematically searched from the inceptio...

authors： Li ZC,Pu YC,Wang J,Wang HL,Zhang YL

更新日期：2021-12-01 00:00:00

abstract：:New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation rate due to the low fidelity of RNA polymerase. To study the single nucleotide polymorphisms (SNPs) dynamics of SARS-CoV-2, 158 SNPs with high conf...

authors： Gao R,Zu W,Liu Y,Li J,Li Z,Wen Y,Wang H,Yuan J,Cheng L,Zhang S,Zhang Y,Zhang S,Liu W,Lan X,Liu L,Li F,Zhang Z

更新日期：2021-12-01 00:00:00

abstract：:The coordinated regulation of the nucelar envelope (NE) reassembly during cell division is an essential event. However, there is little information on the molecular components involved in NE assembly in plant cells. Here we developed an in vitro assay of NE assembly using tobacco BY-2 cultured cells. To start the NE a...

authors： Tamura K,Ueda H,Hara-Nishimura I

更新日期：2021-12-01 00:00:00

abstract：:Massive production of reactive oxygen species (ROS) in human periodontal ligament fibroblasts (HPdLFs) by nitrogen-containing bisphosphonates (BPs) is the main factor causing BP-related osteonecrosis of the jaw. Further, oxidative stress and apoptosis of fibroblasts induced by ROS are closely associated with the activ...

authors： Liu D,Du J,Sun J,Li M

更新日期：2021-12-01 00:00:00

abstract：AIMS:Rhythm control using electrical cardioversion (CV) is a common treatment strategy for patients with symptomatic atrial fibrillation (AF). To guide clinical decision making, we sought to assess if electrocardiographic interatrial blocks could predict CV failure or AF recurrence as the phenomenon is strongly associa...

authors： Relander A,Hellman T,Vasankari T,Nuotio I,Airaksinen JKE,Kiviniemi T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The therapeutic effects of tacrolimus (TAC) versus cyclophosphamide (CTX) were not fully illustrated for patients with idiopathic membranous nephropathy (IMN). METHODS:The PubMed, EmBase, Cochrane library, and CNKI were systematically searched throughout March 2020 for randomized controlled trials evaluatin...

authors： Huang H,Liang Z,Zheng X,Qing Q,Du X,Tang Z,Wei M,Wang C,Zhong Q,Lin X

更新日期：2021-12-01 00:00:00

abstract：:Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike other flaviviruses, ZIKV can be sexually transmitted by vaginal intercourse. The healthy vaginal pH ranges from 4.0 to 6.0, reaching values of 6.0-7.0 after semen deposition. Here, we report that low extracellular pH values (ran...

authors： Varese A,Dantas E,Paletta A,Fitzgerald W,Di Diego García F,Cabrerizo G,Erra Diaz F,Defelipe LA,Pallares H,Dodes Traian M,Gamarnik A,Geffner J,Remes Lenicov F,Margolis L,Ceballos A

更新日期：2021-12-01 00:00:00

abstract：:Plant-derived nanoparticles have multi-functionalities owing to their ecological origin and biocompatible nature. A novel and stable silver nanoparticle (AgNP) was reported here using Cyanthillium cinereum (C. cinereum) as a reducing as well as capping agent by rapid microwave-assisted green method. The synthesized na...

authors： Anjana VN,Joseph M,Francis S,Joseph A,Koshy EP,Mathew B

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:Epicardial fat thickness is an interesting parameter of early atherosclerosis. We prospectively assessed whether weight loss following laparoscopic sleeve gastrectomy (LSG) leads to a significant reduction in the epicardial fat thickness (EFT) and the correlation between the decline in the epicardial fat thickn...

authors： Salman AA,Salman MA,Soliman A,Youssef A,Labib S,Helmy MY,Marie MA,Shawkat M,Mostafa A,Tourky MS,Sarhan MD,Qassem MG,Shaaban HE,Omar MG,Abouelregal TE

更新日期：2021-12-01 00:00:00

abstract：:Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8 protein of SARS-CoV-2 is highly immunogenic and shows high sensi...

authors： Wang X,Lam JY,Chen L,Au SW,To KKW,Yuen KY,Kok KH

更新日期：2021-12-01 00:00:00

abstract：:Preeclampsia (PE) is a severe medical disorder during pregnancy and there has been controversy about the effects of vitamin E on PE. This research intended to explore if δ-tocotrienol (δ-TT), an isomer of vitamin E, could impact PE. Preeclamptic and normal placentas were obtained and total RNA was extracted. The expre...

authors： Shi M,Chen X,Li H,Zheng L

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of elastin fragmentation. This study tried to explore the association between serum EDPs and abdominal aortic calcification (AAC) in PD p...

authors： Zhao S,Cao J,Li J,Yang X,Cao P,Lan J,Lu G

更新日期：2021-12-01 00:00:00

abstract：:We here report a study on the activation of the ι-class bacterial CA from Burkholderia territorii (BteCAι). This protein was recently characterised as a zinc-dependent enzyme that shows a significant catalytic activity (kcat 3.0 × 105 s-1) for the physiological reaction of CO2 hydration to bicarbonate and protons. Som...

authors： De Luca V,Petreni A,Carginale V,Scaloni A,Supuran CT,Capasso C

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Substance use disorders (SUDs) are based on pathophysiological mechanisms common to all psychoactive substances. However, general practitioners (GPs) hold different views depending on the substance in question. OBJECTIVES:To determine whether the perceptions that teaching GPs and final-year residents in gen...

authors： Rouillon M,Laporte C,Ingrand P,Castéra P,Di Patrizio P,Messaadi N,Binder P,Dupouy J

更新日期：2021-12-01 00:00:00

abstract：:Despite a relatively permissive abortion law, women in the Netherlands encounter difficulties in accessing abortion care. Little is known about their experiences. This study explores women's experiences with (online) abortion services and relevant health professionals' experiences delivering care, with the goal of ide...

authors： Holten L,de Goeij E,Kleiverda G

更新日期：2021-12-01 00:00:00

abstract：:Psoriasis vulgaris is a common chronic and recurrent inflammatory skin disease. In clinical practice, acitretin is the first-line treatment drug for psoriasis vulgaris. MicroRNAs (miRNAs) play a vital role in the initiation and development of psoriasis vulgaris. However few studies focused on the mechanisms of acitret...

authors： Chen L,Li J,Yao Y,Wang S,Zheng S,Ju X,Zhang B

更新日期：2021-12-01 00:00:00

abstract：:Online learning has become the new normal in many medical and health science schools worldwide, courtesy of COVID-19. Satisfaction with online learning is a significant aspect of promoting successful educational processes. This study aimed to identify factors affecting student and faculty satisfaction with online lear...

authors： Elshami W,Taha MH,Abuzaid M,Saravanan C,Al Kawas S,Abdalla ME

更新日期：2021-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network a...

authors： Liao R,Ma QZ,Zhou CY,Li JJ,Weng NN,Yang Y,Zhu Q

更新日期：2021-12-01 00:00:00

abstract：:Full thickness cutaneous wound therapy and regeneration remains a critical challenge in clinical therapeutics. Recent reports have suggested that mesenchymal stem cells exosomes therapy is a promising technology with great potential to efficiently promote tissue regeneration. Multifunctional hydrogel composed of both ...

authors： Li Q,Gong S,Yao W,Yang Z,Wang R,Yu Z,Wei M

更新日期：2021-12-01 00:00:00

abstract：SUBSTANCE:We reviewed the effect of a hybrid remediation model combining co-regulated learning and deliberate practice on future exam performance of pre-clerkship medical students who had been unsuccessful on a previous clinic skills exam. With this remediation model, we aimed to strengthen students' self-regulated lea...

authors： Yonder S,Pandey J

更新日期：2021-12-01 00:00:00

abstract：:Alzheimer's disease is a degenerative disorder characterized by the loss of synapses and neurons from the brain, as well as the accumulation of amyloid-based neuritic plaques. While it remains a matter of contention whether β-amyloid causes the neurodegeneration, β-amyloid aggregation is associated with the disease pr...

authors： Ackleh AS,Elaydi S,Livadiotis G,Veprauskas A

更新日期：2021-12-01 00:00:00

abstract：:Doctor Apolinary Tarnawski (1851-1943) was undoubtedly the precursor of modern natural medicine, preventive medicine, and geriatric physiotherapy in Poland. Based on the experience gained from foreign scientific travel, own knowledge and experience, he developed an original method that he successfully used in his own ...

authors： Migala M,Jandziś S

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Becoming widowed is a stressful health-threatening event causing major life changes. We explored how widowed people experience becoming widowed and examined if these experiences are quantitatively associated with widowhood. Methods: A multi-methods study using an exploratory sequential mixed-methods approach ...

authors： Blanner C,Elliott A,Hjorth P,Søndergaard J,Mattisson C,Andersen K

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:As the terpenoid oxide extracted from Eucalyptus L. Herit (Myrtaceae), eucalyptol (EUC) has anti-inflammatory and antioxidant effects. OBJECTIVE:To evaluate the neuroprotective role of EUC in subarachnoid haemorrhage (SAH). MATERIALS AND METHODS:Sprague-Dawley rats were divided into 4 groups: sham group, SAH ...

authors： Xu G,Guo J,Sun C

更新日期：2021-12-01 00:00:00

abstract：:Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieiti...

authors： Miao Y,Han P,Hua D,Zhou R,Guan Z,Lv Q,Dai X

更新日期：2021-12-01 00:00:00